Achievements
原著論文・総説
Hilda Mardiana Pratiwi, Masahiro Hirasawa, Kohki Kato, Keijiro Munakata, Shogo Ueda, Yuuta Moriyama, Reiko Yu, Toru Kawanishi, and Mikiko Tanaka(2023). Heterochronic development of pelvic fins in zebrafish: possible involvement of temporal regulation of pitx1 expression. Front Cell Dev Biol 2023; 11: 1170691. DOI: https://doi.org/10.3389/fcell.2023.1170691
Satomi F Ono, Ingrid Rosenburg Cordeiro , Osamu Kishida, Haruki Ochi and Mikiko Tanaka(2023). Air-breathing behavior underlies the cell death in limbs of Rana pirica tadpoles. Zoological Letters 9, 2. DOI: https://doi.org/10.1186/s40851-022-00199-x
Ingrid Rosenburg Cordeiro, Reiko Yu and Mikiko Tanaka (2020). Regulation of the limb shape during the development of the Chinese softshell turtles. Evol. Dev. 2020, e12352.
Ingrid Rosenburg Cordeiro, and Mikiko Tanaka (2020). Environmental Oxygen is a Key Modulator of Development and Evolution: From Molecules to Ecology. BioEssays 42, 202000025. DOI: https://doi.org/10.1002/bies.202000025
Ingrid Rosenburg Cordeiro, Kaori Kabashima, Haruki Ochi, Keijiro Munakata, Chika Nishimori, Mara Laslo, James Hanken, and Mikiko Tanaka (2019). Environmental oxygen exposure allows for the evolution of interdigital cell death in limb patterning. Developmental Cell 50, 155-166. DOI: https://doi.org/10.1016/j.devcel.2019.05.025
Kenta Kawahata*, Ingrid Rosenburg Cordeiro*, Shogo Ueda, Guojun Sheng, Yuuta Moriyama, Chika Nishimori, Reiko Yu,
Makoto Koizumi, Masataka Okabe, and Mikiko Tanaka (2019). Evolution of the avian digital pattern. Scientific Reports 9, article number 8560. (*These authors contributed equally to this work)
Localization of β-catenin and Islet in the pelvic fin field in zebrafih. Zoological Science 36, 365-371.
Development, Growth & Differentiation Special Issue “Ecology, Evolution and Development” 61, 3-4. (invited)
Involvement of HGF/MET signaling in appendicular muscle development in cartilaginous fish. Development, Growth & Differentiation Special Issue “Ecology, Evolution and Development” (*These authors contributed equally to this work) (invited) 61, 97-103.
Reiko Yu, Ryuichiro Nakato, Katsuhiko Shirahige, and Mikiko Tanaka (2019). Cux2 refines the forelimb field by controlling expression of Raldh2 and Hox genes. Biology Open 8, bio040584.
transition in the mudskipper (Periophthalmus modestus). Zoological Letters 4, 23. doi: 10.1186/s40851-018-0105-z.
Alterations in anterior-posterior patterning and its accompanying changes along the proximal-distal axis during the fin-to-limb transition. Genesis 56, e23053. (Invited)
Mikiko Tanaka (2017). Migratory appendicular muscles precursor cells in the common ancestor to all vertebrates Nature Ecology & Evolution 1, 1731-1736. DOI: 10.1038/s41559-017-0330-4.
Mikiko Tanaka (2017). Evolution of vertebrate limb development (version 2). Essential for Life Sciences doi: 10.1002/9780470015902.a0002099.pub2. (Invited)
Shogo Ueda, Takayuki Suzuki and Mikiko Tanaka (2017).
Transgene introduction into the chick limb bud by electroporation. Methods in Molecular Biology: Avian and reptilian Developmental Biology. 1650, 203-208. doi: 10.1007/978-1-4939-7216-6_13. (Invited)
Expression patterns of Sema3A in developing amniote limbs: with reference to the diversification of peripheral nerve innervation. Dev. Growth Differ. 59, 270-285. doi: 10.1111/dgd.12364.
The fin to limb transition as the re-organisation of a Turing pattern. Nature Communications 7, Article number 11582
Developmental mechanism of limb field specification along the anterior-posterior axis during vertebrate evolution. J. Dev. Biol. 4, 18. (Invited)
Fins into limbs: autopod acquisition and anterior elements reduction by modifying gene networks involving 5’Hox, Gli3 and Shh. Dev. Biol. 413, 1-7
PICCORO:A technique for manipulating the activity of transcription factors with blue light. Methods in Cell Biology: The Zebrafish, 4th edition, Volume 3-Genetics, Genomics, and Transcriptomics. 135, 289-295. doi: 10.1016/bs.mcb.2016.03.009. (Invited)
A shift in anterior-posterior positional information underlies the fin-to-limb evolution. eLife DOI: http://dx.doi.org/10.7554/eLife.07048
Anterior migration of lateral plate mesodermal cells during embryogenesis of the pufferfish Takifugu niphobles: Insight into the rostral positioning of pelvic fins. J. Anat. 227, 81-88.
Development of the lateral plate mesoderm in medaka Oryzias latipes and Nile tilapia Oreochromis niloticus: insight into the diversification of pelvic fin position. J. Anat. 225, 659-674.
Kohsuke Kataoka, Katsuhiko Shirahige, Cheryll Tickle and Mikiko Tanaka (2014). Dimeric combinations of MafB, cFos and cJun control the apoptosis-survival balance in limb morphogenesis. Development 141, 2885-2894. [PubMed] This paper is recommended by Faculty of 1000.
Blue light-mediated manipulation of transcription factor activity in vivo. ACS Chem. Biol. 8, 2649-2653. [PubMed]
field specification and limb initiation. Dev. Growth Differ. 55, 149-163. (Invited) [PubMed]
Evol. Dev. 14,412-420 [PubMed]
Tanaka* (2011). Photoporation of biomolecules into single cells in living vertebrate embryos induced by a femtosecond laser amplifier. PLoS One 6, e27677.(*Co-corresponding authors. These authors contributed equally to this work.) [PubMed]
Dev. Biol. 355, 164-172. (*Co-corresponding authors.) [PubMed]
pelvic fins among teleost fishes. Evol. Dev. 13, 380-388. [PubMed]
Mikiko Tanaka(2010). Allometric growth of the trunk leads to the rostral shift of the pelvic fin in teleost fishes. Dev. Biol.. 347, 236-245. (*These authors contributed equally to this work) [PubMed]
japonicum. Evol. Dev. 12, 34-44. [PubMed]
leads to morphological changes during vertebrate fin evolution. PLoS ONE, 4, e5121. (*These authors contributed equally to this work) [PubMed]
Encylopedia of Life Sciences.
Mikiko Tanaka (2008). Identification of four Engrailed genes in the Japanese river lamprey, Lethenteron japonicum. Dev.Dyn. 237, 1581-1589 [PubMed]
Shimogori and Norihiro Okada (2008). Possible involvement of SINEs in mammalian-specific brain formation. Proc. Natl. Acad. Sci. U. S. A. 105, 4220-4225. [PubMEd]
patterned scales in the embryonic cat shark tail. Biol. Lett.. 4, 87-90. This paper is evaluated as one of ‘Hidden jewels” paper by Faculty of 1000. [PubMed]
Paul Buxton, Despina Stamataki, Mikiko Tanaka, Andrea E Munsterberg, James Briscoe, Cheryll Tickle and Dave W Burt (2006). The Chicken talpid3 gene encodes a novel protein essential for hedgehog signaling. Genes & Dev. 20, 1365-1377. This paper is evaluated as one of ‘Exceptional” paper by Faculty of 1000. [PubMed]
and John H Postlethwait (2005). Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes. Dev. Biol. 281, 227-239 [PubMed]
gene and clues to the basis of morphological diversification of three-spine sticklebacks. Curr. Biol. 13, R951-R952. [PubMed]
factor-induced gene expression and cartilage pattern formation in chick limb bud recombinants. Develop. Growth & Differ. 43, 165-175. [PubMed]
Hiroyuki Ide (1998). Apical ectodermal ridge induction by the transplantation of En-1- overexpressing ectoderm in chick limb bud. Develop. Growth & Differ. 40, 423-429. [PubMed]
expression of Hoxa-11 and Hoxa-13 during limb muscle patterning. Development 125, 1325-1335 [PubMed]
acid synthesis, modifies chick limb development. Dev. Biol. 175, 239-247 [PubMed]
著書
田中幹子、小野沙桃実(2021)酸素が形をつくる仕組み〜酸素による「指間細胞死」誕生のシナリオ、[特集]進化の制約と方向性―微生物から多細胞生物までを貫く表現型進化原理の解明「生物の科学 遺伝」エヌ•ティー•エス、Vol. 76, No.1, pp38-43.
田中幹子(2020)2-5-12 脊椎動物の上陸、2-5 動物の進化の歴史、第2章 動物の進化「動物の事典」、朝倉書店
田中幹子(2020)水面の壁を越える〜大気中の酸素が形をつくるしくみ〜、比較内分泌学、Vol.46 No.170, pp89-91.
田中幹子(2018) 鰭形成に関る遺伝子、第9章 遺伝、「魚類学の百科事典」日本魚類学会編、丸善出版
田中幹子 (2018) 肢芽の形のできかた、第6章 動物の発生、「動物学の百科事典」(第6章「動物の発生」高宗和史、田中幹子 編)日本動物学会編、丸善出版
田中幹子(2013)レーザー技術を応用した発生学研究の新展開、第79回レーザー加工学会論文集、一般社団法人レーザー加工学会、pp31-35
田中幹子(2013)四肢の起源、形態進化のロジックを辿る-エボデボ研究最前線[動物篇]、「生物の科学 遺伝」67, 170-177.
田中幹子、鬼丸洸(2012):脊椎動物が体壁に対鰭を獲得するまでの長い道のり、「特集:複合適応形質進化の遺伝子基盤」、生物科学 63, 166-174.
Mikiko Tanaka and Cheryll Tickle (2006): Fins/limbs in the study of development. In Fins to Limbs. Brian Hall, ed. University of Chicago Press, Chicago.pp65-78
日刊工業新聞 3 月 22 日掲載
バイオサイエンスとインダストリー 64, 21-24.
Mikiko Tanaka (2003): Origin of vertebrate limbs. In Development of vertebrate limbs (in Japanese). Hiroyuki Ide, ed. ICP, Tokyo. pp. 1-19.
Mikiko Tanaka (2003): Dorsoventral patterning of vertebrate limbs. In Development of vertebrate limbs (in Japanese). Hiroyuki Ide, ed. ICP, Tokyo. pp. 119-132.
受賞
科研費・助成金
「外的ストレスが創出する新奇形質」
「脊椎動物の陸上進出による新奇形質の誕生—環境変化により揺らぐ形態形成経路に迫る−」
「脊椎動物における対鰭筋の進化の分子機構」
「形態パターンのゆらぎを生み出すシステムへの構成的アプローチ」
「形態パターンに“ゆらぎ”を与える要因に迫る進化発生学的アプローチ」
「脊椎動物の上陸に伴う四肢での細胞死システムの確立」
「形態パターンのゆらぎを生み出すエピジェネティックな変化」
「マクロ生態学と遺伝学の融合」
「脊椎動物の陸上進出による環境ストレスがもたらした新たな発生システムの獲得機構」
招聘研究者 Professor Anthony Graham(イギリス)
「鰭から四肢へ−陸棲適応へ向けた形態進化−」(前年度申請に伴い2015年度で終了。)
「光に依存した遺伝子発現調節システムの開発と利用」(研究代表 増田真二)
「脊椎動物の付属肢形態を多様化させたゲノム遺伝子相関」
「高出力フェムト秒レーザーによる哺乳類胚の単一細胞の遺伝子
「フェムト秒レーザーによる動物胚の単一細胞へのバイオナノ粒子物理的導入方法の開発」
「転写因子の二つの活性モードによる四肢−脇腹境界の設定機構」
「硬骨魚類をモデルにした形態多様化メカニズムへのアプローチ」
「脊椎動物の多様化戦略への分子的アプローチ」
「硬骨魚類の多様化戦略−変化する腹鰭の位置設定機構」
「脊椎動物に四肢を獲得させたボディプラン戦略の解明」
「脊椎動物の首から尾に広がる肢形成能獲得の歴史の探究—四肢の起源に迫るー
「肢形成不全機構のフグを用いた解析」
「四肢・対鰭形成を制御する脊椎動物のボディープランの解明」
「肢形成不全機構のフグを用いた解析」
「脊椎動物のボディプランにおける背腹決定機構の研究」
「ニワトリ初期胚肢芽におけるAER 形成機構の研究」
「ニワトリ胚予定肢芽域の背腹境界面にAER が形成される機構の解析」